Project Publications
2006
WP 1
Papers
Alarcon, B., Swamy, M., van Santen, H. M., and Schamel, W. W. A. 2006. T cell antigen receptor stoichiometry: pre-clustering for sensitivity. EMBO Reports, 7: 490-495.
Fernández-Malave, E., Wang, N., Pulgar, M., Schamel, W. W. A., Alarcon, B., and Terhorst, C. 2006. Overlapping functions of human CD3d and mouse CD3g in ab T cell development revealed in a humanized CD3g-deficient mouse. Blood, in press.
Lamers CHJ, Sleijfer S, Vulto AG, Kruit WHJ, Kliffen M, Oosterwijk E, Debets R, Gratama JW, Stoter G. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 24:e20 (Letter to editor).
Martín-Cofreces, N. B., Sancho, D., Fernández, E., Vicente-Manzanares, M., Gordón-Alonso, M., Montoya, M. C., Michel, F., Acuto, O., Alarcón, B., and Sánchez-Madrid, F. 2006. Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J. Immunol., 176: 4201-4207.
Schaft N, Lankiewicz B, Drexhage J, Berrevoets C, Moss DJ, Levitsky V, Bonneville M, Lee SP, McMichael AJ, Gratama JW, Bolhuis RLH, Willemsen R, Debets R. T cell retargeting to Epstein-Barr virus antigens following T cell receptor gene transfer: CD28-containing receptors mediate enhanced antigen-specific interferon-g production. Int Immunol, 2006 18:591.
Risueño, R. M., van Santen, H. M., and Alarcón, B. 2006. A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection. Proc. Natl. Acad. Sci. USA, 103: 9625-9630.
Schamel, W. W. A., Risueño, R. M., Minguet, S., Ortiz, A. R., and Alarcón, B. 2006. A conformational- and avidity-based proofreading mechanism for the TCR•CD3 complex. Trends Immunol., 27: 176-182.
WP2
Papers
Hombach, Verena Schildgen, Claudia Heuser, Ricarda Finnern, David Gilham, Hinrich Abken, T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunology, in press.
Morvinski-Friedman D, A. and Eshhar, Z. 2006, Adoptive Immunotherapy of Cancer Using Effector Lymphocytes Redirected with Antibody Specificity” CCBRM- volume 23, from Elsevier. In Press.
WP 3
Papers
D. Friedmann-Morvinski and Z. Eshhar, Immune gene-therapy using redirected naïve T cells is dependent on concerted triggering through signal I and II. Abstract presented at the Annual Meeting of the American Association of Immunology, 2006.
Hombach, A., Schildgen, V., Heuser, C., Finnern, R., Gilham, D., Abken, H., T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J. Immunol., under revision.
H.W. Kessels, K. Schepers, M.D. van den Boom, D.J. Topham and T.N. Schumacher. J. Immunol. 177:976-982 (2006).
M.A. de Witte, M. Coccoris, M.C. Wolkers, M.D. van den Boom, E. Mesman, J-Y Song, M. van der Valk, J.B. Haanen and T.N. Schumacher. Blood. 108:870-877 (2006).
Willemsen, R. A., Sebestyén, Z., Ronteltap, C., Berrevoets, C., Drexhage, J., Debets, R. J Immunol, 2006 177:991 (2006).
WP4
Papers
Miyara M, Amoura Z, Parizot P, Badoual C, Dorgham D, Trad S, Kambouchner K, Valeyre D, Chapelon-Abric C, Debre P, Piette JC, Gorochov G. 2006. The immune paradox of sarcoidosis and regulatory T cells. J. Exp. Med. 203(2):359-70.
Lamers C, Willemsen R, van Elzakker P, van Krimpen B, Gratama J, Debets R. Phoenix-ampho outperforms PG13 as retroviral packaging cells to transduce human T cells with tumor-specific receptors: implications for clinical immunogene therapy of cancer. Cancer Gene Ther 2006, 13:503.
Pouw NMC, Willemsen RAW, Debets R. Efficient TCR gene transfer in primary murine T cells is improved by pseudotyping with amphotropic and ecotropic envelopes while surface expression requires TCR murinization. Manuscript submitted.
Schaft N, Lankiewicz B, Drexhage J, Berrevoets C, Moss DJ, Levitsky V, Bonneville M,
Lee SP, McMichael AJ, Gratama JW, Bolhuis RLH, Willemsen R, Debets R. T cell retargeting to Epstein-Barr virus antigens following T cell receptor gene transfer: CD28-containing receptors mediate enhanced antigen-specific interferon- production. Int Immunol, 2006 18:591.
Sommermeyer, D., Neudorfer, J., Weinhold, M., Leisegang, M., Engels, B., Noessner, E., Heemskerk, M.H.M., Charo, J., Schendel, D.J., Blankenstein, T., Bernhard, H. and Uckert, W. 2006. Designer T cells by T cell receptor replacement. Eur. J. Immunol. 36(11):3052-3059.
Swainson, L., Verhoeyen, E., Cosset, F.L., and N. Taylor. 2006. IL-7R{alpha} gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J. Immunol. 176: 6702-6708.
Swainson, L., Kinet, S., Mongellaz, C., Sourisseau, M., Henriquez, T. and N. Taylor. 2006. IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood, 17023582 (ahead of print).
WP5
Papers
Lamers, C., Willemsen, R., van Elzakker, P., van Krimpen, B., Gratama, J., and Debets, R. (2006) Phoenix-ampho outperforms PG13 as retroviral packaging cells to transduce human T cells with tumor-specific receptors: implications for clinical immunogene therapy of cancer. Cancer Gene Ther, 13, 503.
Lamers, C. H. J., Van Elzakker, P., Langeveld, S. C. L., Sleijfer S., and Gratama J. W. Process validation and clinical evaluation of a protocol to generate gene modified T lymphocytes for immuno-gene therapy of metatstatic renal cell carcinoma. Cytotherapy, in press.
Jiang HR, Gilham DE, Mulryan K, Kirillova N, Hawkins RE, Stern PL (2006). Combination of vaccine and chimeric receptor expressing T cells provides improved therapy of tumors. Journal of Immunology 177(7): 4288-4298.
Swainson, L., Verhoeyen, E., Cosset, F.L., and N. Taylor. 2006. IL-7R{alpha} gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J. Immunol. 176: 6702-6708.
WP6
Papers
Hombach, A., Schildgen, V., Heuser, C., Finnern, R., Gilham, D., Abken, H., T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J. Immunol., in press
Miyara M, Amoura Z, Parizot P, Badoual C, Dorgham D, Trad S, Kambouchner K, Valeyre D, Chapelon-Abric C, Debre P, Piette JC, Gorochov G. The immune paradox of sarcoidosis and regulatory T cells. J. Exp. Med. 2006 Feb 20;203(2):359-70.
Lamers, C. H. J., Sleijfer, S., Vulto, A. G., Kruit, W. H. J., Kliffen, M., Oosterwijk, E., Debets, R., Gratama, J. W., Stoter, G. (2006) Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol, 24:e20 (Letter to editor).
Kashkar, H., Seeger, J., Deggerich, A., Utermöhlen, O., Heimlich, G., Hombach, A., Abken, H., Krönke, M. XIAP targeting sensitizes Hodgkin´s lymphoma cells for cytolytic T cell attack. Blood, in press